Bio-safety assessment of carbon quantum dots,N-doped and folic acid modified carbon quantum dots: A systemic comparison

The carbon quantum dots(CQDs) and their functionalized materials are promising in biomedical field because of their unique properties;meanwhile,a growing concern has been raised about the potential toxicity of these modified materials in biosystem.In this study,we synthesized original CQDs and two common functionalized CQDs including N-doped CQDs(NCQDs) and folic acid-modified CQDs(FACQDs),and compared the toxicity and biocompatibility with each other in vitro and in vivo.L929,C6 and normal cell MDCK were selected to detect the adverse reaction of these materials in vitro.No acute toxicity or obvious changes were noted from in vitro cytotoxicity studies with the dose of these CQD materials increasing to a high concentration at 1 mg/mL.Among these materials,the FA-CQDs show a much lower toxicity.Moreover,in vivo toxicity studies were performed on the nude mice for 15 days.The experimental animals in 10 or 15 mg/kg groups were similar with animals treated by phosphate buffer solution(PBS) after 15 days.The results of the multifa rious biochemical parameters also suggest that the functionalized products of CQDs do not influence the biological indicators at feasible concentration.Our findings in vitro and in vivo through toxicity tests demonstrate that CQDs and their modified materials are safe for future biological applications.     

Majorana Representation for a Composite System

International Journal of Theoretical Physics - The Majorana representation, which provides an intuitive way to represent the quantum state by stars on the Bloch sphere, has drawn considerable...     

Comparison of PVDF/MWNT,PMMA/MWNT,and PVDF/PMMA/MWNT nanocomposites: MWNT dispersibility and thermal and rheological properties

Pristine multi-walled carbon nanotubes (MWNTs) were incorporated into poly(vinylidene fluoride) (PVDF), poly(methyl methacrylate) (PMMA), and PVDF/PMMA blends to achieve binary and ternary nanocomposites. MWNTs were more compatible with the PVDF matrix than with the PMMA-containing matrices. MWNT addition did not alter the development of α-form PVDF crystals in the binary/ternary composites. Nucleation and overall isothermal crystallization of PVDF were enhanced by the presence of MWNTs, and enhancements were optimal in the PVDF/MWNT binary composites. Avrami analysis revealed that addition of MWNTs led to more extensive athermal-type nucleation of PVDF, and that PMMA slightly decreased the crystal growth dimension of PVDF. The equilibrium melting temperature (T_m°) of PVDF increased in the binary composites but remained nearly constant in the ternary system. Thermal stability was enhanced in the binary/ternary composites, and enhancements were more evident in the air environment than in nitrogen. Rheological property measurements revealed that the intensely entangled chains of high-molecular weight PVDF dominated the rheological response of PVDF-included samples in the melt state. A (pseudo)network structure was developed in each of the PVDF-included samples as well as in the 1 phr MWNT-added PMMA/MWNT composite. The storage moduli of the PVDF, PMMA, and PVDF/PMMA:1/1 blend increased to 37%, 22% and 34%, respectively, at 40 °C after addition of 1 phr MWNT.     

Iodine-catalyzed C3-formylation of indoles using hexamethylenetetramine and air

An efficient iodine-catalyzed chemoselective 3-formylation of free (N–H) and N-substituted indoles was achieved by using hexamethylenetetramine (HMTA) in the presence of activated carbon under air atmosphere. This new method could provide 3-formylindoles in moderate to excellent yields with fairly short reaction times. Moreover, this catalytic formylation of indoles procedure can be applied to gram-scale synthesis.     

Insights into the interactions between DNA and an infinite clamp-like copper (II) complex

Transition Metal Chemistry - A Cu(II) complex [Cu2(phen)2(NAB)2(HO)]n (phen?=?1, 10-phenanthroline and NABH?=?p-N, N-(2-hydroxyethyl)amino benzoic acid) was synthesized, and...     

Crystal structure of solvate [Cd2L2Cl4]·CH2Cl2 (L = pyrazolylquinoline, the derivative of monoterpenoid (+)-3-carene) and photoluminescence of chiral complex CdLCl2

Using the single crystal X-ray diffraction data (150 K, Bruker X8 Apex CCD autodiffractometer, MoK α radiation), the crystal structure of the [Cd₂L₂Cl₄]·CH₂Cl₂ (L = pyrazolylquinoline, the derivative of monoterpenoid (+)-3-carene) compound is determined. Crystals are monoclinic, unit cell parameters are: a = 10.7005(4) ?, b = 16.8491(4) ?, c = 11.9658(4) ?, β = 93.308(1)°, P2₁ space group. The structure is formed from discrete acentric molecules of a binuclear [Cd₂L₂Cl₄] complex and uncoordinated CH₂Cl₂ molecules. The Cd²⁺ ions coordinate N atoms of bidentate chelating ligands L, which leads to the closure of two five-membered chelate CdN₃C rings. The coordination sphere of Cd atoms also includes three Cl atoms (two bridging and one terminal), consequently, two CdCl₃N₂ coordination sites and a Cd₂Cl₂ metal ring are formed. The Cl₃N₂ polyhedra have the form of distorted tetragonal pyramids. The CH₂Cl₂ molecules located in the channels formed by the complexes are linked with them by weak H-bonds. The excitation spectra of L and the CdLCl₂ compound contain bands with λ_max of 352 nm and 360 nm respectively. At 300 K and λ_excit 350 nm, in the photoluminescence spectrum of L a rather intense broad split band with λ_max 372 nm and 386 nm is observed. The photoluminescence spectrum of the CdLCl₂ compound contains a broad band with λ_max 418 nm. The photoluminescence intensity of this compound is significantly lower than that of L.     

基于磁/惯性传感器旋转弹体定姿的Kalman滤波器设计

微惯性传感器精度较低,其漂移会引起很大的姿态误差,不能提供长时间稳定姿态;磁传感器组合的姿态角误差不随时间累积但姿态角更新速度慢。针对这一问题提出了利用磁/惯性传感器构建低成本姿态探测系统的方案,设计了Kalman滤波器融合二者信息——以磁传感器解算的姿态角和等效旋转矢量法解算的姿态角之差作为观测量,以惯性传感器的漂移和姿态误差角作为状态变量,整个解算过程无需使用地磁场强度。仿真结果表明了该算法的有效性,二者组合定姿可实现高精度的姿态测量。     

Transient chaos in smooth memristor oscillator

This paper presents a new smooth memristor oscillator, which is derived from Chua's oscillator by replacing Chua's diode with a flux-controlled memristor and a negative conductance. Novel parameters and initial conditions are dependent upon dynamical behaviours such as transient chaos and stable chaos with an intermittence period and are found in the smooth memristor oscillator. By using dynamical analysis approaches including time series, phase portraits and bifurcation diagrams, the dynamical behaviours of the proposed memristor oscillator are effectively investigated in this paper.     

Limits on rough-particle sizing with low-defocus interferometric imaging

We present a rigorous theoretical model for the influence of the aperture in interferometric out-of-focus imaging. We investigate the role of this effect on the properties of speckle-like patterns generated by irregular, rough particles. Finally, we determine the conditions under which these patterns are no longer representative of particle size but of the aperture itself and the defocus parameter.